In the decapping and deadenylation mediated mRNA decay pathway, what would be the consequence of a mutation that resulted in the CCR4-NOT complex NOT being able to remove the poly(A) tail?

Question

In the decapping and deadenylation mediated mRNA decay pathway, what would be the consequence of a mutation that resulted in the CCR4-NOT complex  NOT  being able to remove the poly(A) tail?

Answer

The rate of exosome-mediated decay would be reduced

Answer

The rate of mRNA decay would be reduced, but the 3’ to 5’ pathway (exosome) would be able to degrade mRNA

Answer

The poly(A) tail length would be extended, stabilising the mRNA

Answer

No consequence, as the nonsense-mediated mRNA decay (NMD) would be used to decay the mRNAs

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In the decapping and deadenylation mediated mRNA decay pathway, what would be th...

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