Ionotropic receptors (receptors that form ion channels) and metabotropic receptors (receptors linked to G proteins) differ in that

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Ionotropic but not metabotropic receptors directly modulate the on-going movement of ions

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Ionotropic but not metabotropic receptors have regulatory sites to modulate the binding of ligands

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Ionotropic but not metabotropic receptors show different affinities for chemical agents

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Ionotropic but not metabotropic receptors undergo a conformational change after binding ligand

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Ionotropic but not metabotropic receptors show specificity for ligands

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