A patient with RA is started on leflunomide. What is a critical piece of pre-therapy counseling regarding the drug's long half-life?

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It has a very long half-life; if toxicity occurs or pregnancy is desired, a cholestyramine washout is required to accelerate drug elimination.

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It has an immediate onset of action.

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It can be stopped abruptly without any withdrawal effects.

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It can be taken with cholestyramine to enhance its absorption.

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It is safe in patients with pre-existing liver disease.

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