B cells recognize only processed peptide fragments, while T cells recognize whole, native proteins

B cells recognize antigens via MHC II molecules, while T cells use MHC I

T cells, more precisely the TCR, require antigens to be processed and presented on MHC molecules, whereas B cells, more precisely the BCR, can recognize soluble, intact antigens

B cells require "co-stimulation" from dendritic cells to recognize an antigen, while T cells do not

B cells utilize toll-like receptors (TLRs) as their primary antigen-specific receptor, whereas T cells utilize the TCR