Normal haemoglobin is a tetramer, consisting of two molecules of β haemoglobin and two molecules of α haemoglobin. In sickle-cell disease, as a result of a single amino acid change, the mutant haemoglobin tetramers associate with each other and assemble into large fibres. Based on this information alone, we can conclude that sickle-cell haemoglobin exhibits ________.

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Only altered secondary structure, the primary, tertiary and quaternary structures remain the same

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Only altered primary structure, the quaternary structure is not altered

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Only altered tertiary structure, the primary structure is not altered

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Only altered secondary structure, the primary structure is not altered

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Altered primary structure and altered quaternary structure, the secondary and tertiary structures may or may not be altered

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Normal haemoglobin is a tetramer, consisting of two molecules of β haemoglobin a...

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