Consider the developmental
pathways of mesenchymal stem cells and the therapeutic targets for adult body
weight regulation. Which of the following integrates a developmental growth
factor function with its corresponding adult tissue metabolic application?

Question

Accepted Answer

FGF21, which developmentally specifies the Myf5- lineage into brown pre-adipocytes, is produced in adult WAT and can act in an autocrine/paracrine manner to regulate browning and thermogenesis

Answer

Wnts, which developmentally promote brown pre-adipocyte differentiation, are used in adults to stimulate thermogenesis.

Answer

Myostatin, which developmentally acts as a positive regulator of skeletal muscle growth, is inhibited in adults to cause muscle wasting.

Answer

Irisin, which developmentally acts as a negative regulator of myocytes, is targeted in adults to block the trans-differentiation of brown adipocytes.

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Consider the developmental pathways of mesenchymal stem cells and the therapeuti...

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