Thinking about T cell development which generates our peripheral T cell repertoire and then how T cells behave in the periphery. If a T cell has undergone positive selection in the thymus following interaction with the MHC molecule HLA-A, then:

Question

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The interaction of T cells with HLA-A in the thymus is to identify T cells to be deleted to avoid autoimmunity.

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Pathogen peptide x that is presented by any of the HLA molecules (HLA-A, -B or -C) may activate that T cell.

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The same peptide presented to the T cell by HLA-A during development needs to be presented in the periphery for that T cell to be activated.

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Pathogen peptide x that is presented by HLA-A may activate that T cell.

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Thinking about T cell development which generates our peripheral T cell repertoi...

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