A researcher is studying a solid
tumour in a preclinical model. Genetic or pharmacologic interventions have
blocked angiogenesis, preventing the tumour from forming new blood vessels. The
tumour remains viable but shows changes in its growth and behaviour compared to
untreated controls.

Which aspect of tumourigenesis is most
directly limited by the absence of angiogenesis?

Question

A researcher is studying a solid
tumour in a preclinical model. Genetic or pharmacologic interventions have
blocked angiogenesis, preventing the tumour from forming new blood vessels. The
tumour remains viable but shows changes in its growth and behaviour compared to
untreated controls.

Which aspect of tumourigenesis is most
directly limited by the absence of angiogenesis?

Answer

Immune cell
infiltration into the tumour

Answer

Recruitment of
cancer-associated fibroblasts to the tumour microenvironment

Answer

Migration and
invasion into of the tumour into surrounding tissues

Answer

Tumour
growth beyond ~2 mm in diameter, due to insufficient nutrient and oxygen
delivery

Crowdly

A researcher is studying a solid tumour in a preclinical model. Genetic or phar...

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