In a tumour sample, genomic analysis
reveals that a cell initially carried one mutated allele and one normal allele
of a tumour suppressor gene. Sequencing of the advanced tumour weeks later reveals
that the remaining functional allele has been deleted through a chromosomal cross-over
event, leaving the cell without any functional copies of the gene.

Which concept BEST describes this
genetic event?

Question

In a tumour sample, genomic analysis
reveals that a cell initially carried one mutated allele and one normal allele
of a tumour suppressor gene. Sequencing of the advanced tumour weeks later reveals
that the remaining functional allele has been deleted through a chromosomal cross-over
event, leaving the cell without any functional copies of the gene.

Which concept BEST describes this
genetic event?

Accepted Answer

A
somatic event that removes the remaining functional allele of a tumour
suppressor gene

Answer

A mutation that
inactivates both alleles of a tumour suppressor gene

Answer

Amplification of a
growth-promoting oncogene leading to increased signalling activity

Answer

A germline mutation
that activates a proto-oncogene

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In a tumour sample, genomic analysis reveals that a cell initially carried one ...

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