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MED-304 Pathology I (2025-26)

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A 68-old-year

male was brought to the Emergency Unit of the hospital after having experienced

a sudden onset of dyspnoea and tachypnoea together with pleuritic chest pain.

The laboratory findings showed the following: P

aCO2

:

<33mmHg, P

aO2

: <80mmHg and increase in A-a gradient.

Other investigations performed included ventilation and perfusion scan as well

as measurement of D-dimers and the diagnosis of pulmonary embolism was made.

 

Which imaging/laboratory

findings are most likely to be observed in this condition?

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A premature infant was brought to the Pathology Department for autopsy,

after having been unexpectedly found dead in his bed. Histopathological

examination of the lungs revealed the presence of intra-alveolar hyaline

membranes leading to a diagnosis of hyaline membrane disease.

 

What is

the most likely cause for the development of this condition?

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A 54-year-old

male came to ENT doctor complaining of nasal obstruction and epistaxis. Rhinoscopy

revealed a tumour on the nasal diaphragm. Microscopic examination showed a

neoplasm with an endophytic pattern of growth, forming finger-like projections

in the underlying tissue, consisting of the typical cylindrical epithelium of

airway tract with an increase in the number of cylindrical rows.

 

Which tumour

corresponds better to the aforementioned clinico-pathologic findings?

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An 8-year-old

girl was brought to the paediatrician showing a bull-neck appearance with a

distinct collar of swelling. The ENT examination revealed a superficial dirty

grey pseudo-membrane covering the tonsils. The microscopic investigation of

this structure showed that this consisted of a fibrino-purulent exudate with

intermingled microorganisms.

 

Which pathogen

is most likely responsible for these clinico-pathologic findings?

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A 64-year-old woman visited her family doctor, complaining of headaches,

sweating and heart palpitations. Furthermore, she mentioned that she

experienced generalized weakness which she thought was due to weight loss.

After repetitive measurements of the patient’s blood pressure the doctor

diagnosed hypertension and asked for a CT of her abdomen. The results of the

latter showed a mass located adjacent to the upper pole of the right kidney.

 

Which tumour would be the most likely cause for the symptomatology

described above?

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A 52-year-old

woman came to the GP complaining of a painful, red and warm left leg. She also

had pain in her back. The doctor’s final diagnosis, after a thorough

examination and laboratory testing, was a deep vein thrombosis associated with

a pancreatic adenocarcinoma. 

 

Which

syndrome describes the coexistence of these diseases?

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A 3-year-old

boy was brought to the paediatrician after his parents had noticed

reddish-purple spots (rash) on the buttocks, legs and feet. Moreover, they also

reported abdominal pain with nausea and vomiting. Further examinations

performed by the doctor led to a diagnosis of glomerulonephritis. A skin biopsy

of the lesions revealed leukocytoclastic vasculitis and venular thrombosis

whereas IgA immune complex deposition was identified within the wall and lumen

of the dermal vessels.

 

Which

vasculitis is most likely responsible for the above clinicopathological findings?

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While drinking coffee with her

husband at home, a 56-year-old woman experienced a sudden excruciating headache

and was brought to the Emergency Unit. CT of the brain revealed subarachnoid

haemorrhage.

 

What is the most likely cause of

her haemorrhage?

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A 19-year-old male adult was brought to the Emergency Unit of the local

hospital after having experienced fatigue, dyspnea and palpitations. In the

subsequent endomyocardial biopsy a histopathological diagnosis of myocarditis

was made.

 

Which pathogen would most likely be expected to be responsible for the

myocarditis?

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Given that the autopsy was performed within 24 hours of the infarction,

which microscopic characteristics would be most likely observed histopathologically?

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