In which ECG leads would

alterations associated with this myocardial infarction be most likely expected?

The autopsy

examination of the heart of a 58-year-old man revealed marked ventricular

enlargement. However, in his past medical history there was no congenital,

valvular, or coronary artery disease.  In

addition, no hypertensive disease was previously diagnosed. The

histopathological examination identified perinuclear brown deposits within the

cardiomyocytes in the routine H&E stain; the deposits were shown to

represent iron accumulation, and finally a diagnosis of haemochromatosis was

made.

Which type of

cardiomyopathy is most likely associated with this condition?

A 52-year-old woman patient presents to her family doctor complaining of

palpitations, dizziness and lightheadedness. An ECG is performed as shown below.

Figure 1. 

Which diagnosis most likely corresponds to the ECG trace?

A 45-year-old woman presents to the

hospital complaining of difficulty in breathing when lying flat, chest

tightness, dizziness and fainting. Imaging identifies a pedunculated mass

within the left atrium, which is attached to the interatrial septum. Histopathological

evaluation describes characteristic “lepidic” cells within an abundant

mucopolysaccharide matrix. Further investigations reveal an association of the

tumour with the Carney complex.

Which neoplasm is most likely present?

The autopsy investigation of a 67-year-old man reveals a characteristic

“fish mouth” appearance of his mitral valve. The pathologist finds out from the

medical history that the patient was suffering from rheumatic heart disease

consistent with his primary hypothesis.

Which

organism is most likely responsible for this valve alteration?

Among the refugees in a UN camp, a general practitioner (GP) noticed a

child because of a typical squatting position accompanied with cyanosis and

clubbing of its fingers. This is a characteristic clinical presentation of a

particular congenital heart disorder.

Which pathological features are associated with the above diagnosed

congenital heart disorder?

A 56–year-old man visited the urologist complaining of urinary retention

and haematuria together with back pain. His PSA was raised and imaging studies

revealed a tumour mass originating from the prostate with metastases to the

spine. Prostatic adenocarcinoma was diagnosed on histopathological evaluation.

What system is used by the pathologist in the grading of these tumours?

A 6-year-old boy playing

outside in the backyard fell down and wounded himself on the right leg.

What combination of signs

will be present in the injured tissue as a result of the inflammatory response?

An 8-year-old

boy was playing football with his friends in the schoolyard when he fell down

and wounded his right knee. In the evening at home his mother noticed that the

injured area had become inflamed.

Which

combination of parameters would result in accumulation of extravascular fluid

in his body’s inflammatory response?

A 47-year-old woman sustained a cut in her right hand. The site of the

cut appeared inflamed by the next day.

Which events, placed in the correct order, took place during the

migration of leucocytes to the wound region?