1: Basophil, 2: Lymphocyte, 3: Basophil, 4: Neutrophil

1: Eosinophil, 2: Lymphocyte, 3: Neutrophil, 4: Basophil

1: Neutrophil, 2: Lymphocyte, 3: Eosinophil, 4: Basophil

1: Neutrophil, 2: Macrophage, 3: Lymphocyte, 4: Basophil

Afferent lymphatics

Efferent lymphatics

Arterial blood flow

Venous blood flow

The target antigen

The constant region

The binding affinity

The variable region

Will not display any peptides in the MHC binding cleft

Will display the invariant chain (Ii) from CLIP in the binding cleft

Will display self-peptides in the MHC binding cleft

Will not be transported to the surface of the cell

The localisation of a TLR with the cell determines which PAMP it recognises

They generate pro-IL-1

Each TLR can bind a broad range of PAMPs

All TLRs are expressed on (or in) each innate immune cell

1: Basophil, 2: Lymphocyte, 3: Basophil, 4: Neutrophil

1: Neutrophil, 2: Lymphocyte, 3: Eosinophil, 4: Basophil

1: Eosinophil, 2: Lymphocyte, 3: Neutrophil, 4: Macrophage

1: Neutrophil, 2: Macrophage, 3: Lymphocyte, 4: Basophil

Provide structural support for these organs

Act as a barrier to separate the T and B lymphocytes within these organs

Are the exit points for lymphoid cells to drain from the organ into the lymphatics

Are the site where the lymphoid cells enter the organ from the blood circulation

All TLRs that bind bacterial products are found on the surface of leukocytes.

It first binds to microbe within the cell and exports it to the surface to promote phagocytosis.

It can interact with a wide range of different structures and is a good early alarm signal.

It provides the best opportunity to interact with its target structure which is located on the surface of the microbe.

C3b and C3a are also key molecules that go on to form the MAC associated with complement activation.

To provide a means for phagocytes to identify

To promote inflammation and attract innate

leukocytes to the site of infection.

To encircle the bacteria and prevent any further

replication.