The expression of new heavy chains

The expression of new light chains

The recombination of completely new heavy and light chains

The induction of point mutations in the immunoglobulin genes altering the amino acid sequence at the binding site

Secretion of natural antibody into the circulation

Opsonisation with C3b

Neutralising PAMPs on the bacterial surface

Generation of the membrane attack complex

1: Lymphocyte, 2: Basophil, 3: Neutrophil, 4: Eosinophil

1: Basophil, 2: Lymphocyte, 3: Eosinophil, 4: Neutrophil

1: Neutrophil, 2: Lymphocyte, 3: Eosinophil, 4: Basophil

1: Eosinophil, 2: Lymphocyte, 3: Neutrophil, 4: Basophil

Avidity

Complementarity attraction

Affinity

Adhesion binding relationship (ABRS)

NK cells function by engagement of the NK-specific TCR on the NK cell surface

NK cells only kill cells that are infected with viruses or obligate intracellular bacteria

NK cells directly kill target cells by binding of the TLR on the NK cell surface with the target cell structure

NK cells directly kill target cells if they do not receive an inhibitory signal from the target cell