Alter conformational sites

Cause refractory activation

Block activation sites

Bind to inactivation sites

Activate regulatory sites

Speed, Flexibility and Plasticity

Binding, Regulation and Specificity

Specificity, Affinity and Saturation

Thoughfulness, Mindfullness and Strength

Diversity, Amplification, Multiple control sites

can bind to an activated receptor to become activated in turn

act as receptors for lipid-soluble chemical agents

always produce their effect by producing 2nd messengers

act as receptors forming ion channels

are bound to the DNA

Activation of already expressed proteins

All of the above

Opening of ion channels and hyperpolarization of the resting membrane potential

Opening of ion channels and depolarization of the resting membrane potential

 Synthesis of new proteins

They both activate 2nd messengers when ligand binds to appropriate sites

They both allow in ions when ligand binds to appropriate sites

They both inactivate 2nd messengers when ligand binds to appropriate sites

They both are activated by ligands bind to appropriate sites on the receptor

They both modulate the on-going movement of ions when ligand binds to appropriate sites

All of the above are true

The binding site is normally a hollow or cleft in the surface of the receptor

Chemical messengers fit into binding sites and bind to functional groups within the binding site

The binding site is normally hydrophobic in nature

The binding site contains amino acids which are important to the binding process to catalyse the reaction

Unlike receptors for water-soluble chemical signals, those for lipid-soluble signals show the property of affinity only

Unlike receptors for lipid-soluble chemical signals, those for water-soluble signals show the properties of specificity and affinity

Unlike receptors for water-soluble chemical signals, those for lipid-soluble signals show the properties of specificity and affinity

Unlike receptors for water-soluble chemical signals, those for lipid-soluble signals show the property of specificity only

Unlike receptors for water-soluble chemical signals, those for lipid-soluble signals can act on the DNA

bind to DNA

can be coupled to more than one G protein

are found within the intracellular compartment

can only produce effects via the regulation of ion channel function

are activated by hydrophobic ligands

Acting on Refractory sites

Acting on Inactivation sites

Down regulation

Sequestration

Desensitization