increases the permeability of the presynaptic membrane to Ca++ ions

 increases the permeability of the presynaptic membrane to Na+ ions

causes ligand gated Ca++ channels in muscle fibres to increase permeability to Ca++ to hyperpolarise the postsynaptic membrane due to loss of Ca++

depolarizes the presynaptic membrane by increasing the permeability of Na+

causes ligand gated Na+ channels in muscle fibres to increase permeability, resulting in postsynaptic membrane depolarization

ACh binds to the alpha subunit

Are ionotropic receptors

Non-selective cation channels

ACh binds to the gamma subunit

Feature two binding sites for ACh

The Sympathetic NS post-ganglionc synapse

The Sympathetic NS pre-ganglionc synapse

The Parasympathetic NS post-ganglionc synapse

The synapse with skeletal muscle

The Parasympathetic NS pre-ganglionc synapse

AChE is highly expressed in the pre-synaptic nerve terminal

Docking proteins hold vesicles close to voltage-gated Na+ channels

The neuromuscular junction features a highly folded pre-synaptic density

 Skeletal muscle fibres are innervated by a single motor nerve terminal

Skeletal muscle fibres receive input from multiple nerve terminals

The brain

The ganglion

The CNS

The ANS

The spinal cord

Requires the mitochondria to produce ACh

Requires Choline to combine with Acetyl Coenzyme A in the terminal

Occurs in the cell body and then it is transported to the terminal

Requires Ca⁺⁺ to be present for the production of ACh in the cytoplasm

Requires the action of Acetylcholinesterase (AChE)

The Sympathetic NS post-ganglionc synapse

The Sympathetic NS pre-ganglionc synapse

The Parasympathetic NS post-ganglionc synapse

The synapse with skeletal muscle

The Parasympathetic NS pre-ganglionc synapse

Nicotine blocks these channels as effectively as muscarine

Nicotine blocks the release of the motor neuron's neurotransmitter

Nicotine blocks these channels more effectively than muscarine

Nicotine facilitates the release of the motor neuron's neurotransmitter

Nicotine is a more effective agonist than muscarine at these receptors

a high density of ACh receptors

the largest diameter myelinated neurons

motorneurons and ACh receptors

the largest diameter unmyelinated neurons

a high density of ACh esterase