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BCH2011 - Structure and function of cellular biomolecules - S1 2025

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Amino acids can be classified into different physiochemical groups due to differences in their:

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How many peptide bonds are there in the following peptide sequence?

ValValGlyProAsnAspHisSer

(Enter a number in digits with no additional characters)

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What amino acid(s) are very likely to be buried within a globular protein found in the cytoplasm?

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DNA polymerase, the enzyme responsible for replicating DNA, contains different catalytic subunits that adopt discrete structures. This an example of: 

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Dihedral angles are important in the secondary structure of proteins. Two types of dihedral angles have the greatest impact on peptide conformation, with these derived from rotation around:

(Note that the main-chain atoms of an amino acid backbone are here denoted N–Cα–C)

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Fibrous proteins often have functions related to:

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The image below is a helical wheel representation of part of an alpha helix (top-down view), with each amino acid a numbered circle.

Without knowledge of any R groups, non-covalent interactions between which ONE of the following pairs of amino acids will likely help stabilise the helix?

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Why is cysteine (shown below) able to form disulphide bonds?

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The image below shows aspects of the secondary structure of an important human protein.

Several amino acids are highlighted by a ball and stick representation.

(Note that atoms are coloured by element, where blue is nitrogen and red is oxygen.)

Image failed to load: 4CR2 bonding

Which statement below describes the numbered region?

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The image below shows aspects of the secondary structure of an important human protein.

Two specific amino acids are highlighted by a ball and stick representation.

(Note that atoms are coloured by element, where blue is nitrogen, red is oxygen and yellow is sulphur.)

Image failed to load: 1IGT_bonding

Complete the statement regarding the role of these two amino acids:

This is an example of...

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