Examine the G-banded karyogram of Linda. In the provided patient file pair the atypical chromosomes with the typical versions of chromosomes from which they may have been derived.

Identify the type of chromosomal rearrangement.

Choose which image accurately illustrates Linda's family pedigree:

Interspecies hybrids can arise between the red kangaroo and euro. How many chromosomes are present in somatic cells of the hybrid?

Insert a number only (no spaces)

Meiosis occurs in the

euro and red kangaroo hybrid in Q4. Diagram the expected appearance of the

chromosomes involved at the pachytene stage of prophase I for chromosomes 5 and

6 of the euro and red kangaroo hybrid. 

Would the hybrid in Q4 be completely fertile?

From this tree, which species is the closest relative of the red kangaroo (Macrupus rufus)?

Upload a screenshot from NCBI BLAST showing a nucleotide alignment of the mutant cDNA sequence used in your BLAST search and the corresponding reference gene sequence; include the translated polypeptide sequence of both the variant allele and reference. Just show the region (~500 bp) containing the putative pathogenic (disease causing) mutation – NOT the entire alignment.

Annotate this screen shot to highlight:

i) the location of the variant

ii) the effect of the variant on the protein sequence of the variant allele

(Select all that apply)

Genetic locus:

According to OMIM database, use standard nomenclature: <chromosome><arm><region><G-band.sub-band> with no spaces. If there is a range of sub-bands, only enter the first sub-band.

Example: a gene located on chromosome 7, p arm, Region 3, Band 1 and sub-band 2= 7p31.2 

Only enter 7p31.2