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BMS2052 - Microbes in health and disease - S2 2025

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Q17. A patient with liver cancer, who had previously been infected with the novel virus, presented to the emergency department with fever, cough, and shortness of breath. A chest X-ray revealed a large region of opacity in the left lung (A). A sputum sample was collected, which revealed multicellular hyphae (B). The results are shown below in images A and B.

Which of the following is the most likely diagnosis for this patient?

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Q9. The clinical microbiologist uses a pure culture of GPEC to prepare a heat-fixed smear and performs a Gram stain. The microbiologist accidentally omitted the carbol fuchsin step when performing the Gram stain. What will the microbiologist observe when the Gram-stained GPEC cells are viewed with a light microscope? Select one option (A-F) and briefly justify your response. (1-2 sentences) (2 marks)

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Q20. The patient is particularly susceptible to microbial infection because they carry a mutation that dysregulates the function of the complement protein, C5. Laboratory tests determine that while C5b can be generated normally, C5a is non-functional. Which of the following components of the complement response will be deficient in the patient: inflammation, phagocytosis and/or cell lysis? Briefly justify your response. (2-3 sentences) (2 marks)

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Q19. The treating physician decides to change the patients prescription from a broad-spectrum antibiotic to a narrow-narrow spectrum antibiotic that specifically targets gram-negative bacteria. Which of the following antibiotics should the physician prescribe?

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Q18. Microbial testing results identified Klebsiella pneumoniae as the causative bacterium. K. pneumoniae is a gram negative extracellular pathogen that can modulate its production of outer membrane porins. A reduction in outer membrane porins can result in:

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Q17.

Do you expect ceftazidime to have a bacteriostatic

or bactericidal effect on the causative bacterium? Justify your answer. (1-2

sentences) (2 marks)

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Q15. Following administration of the KVD mRNA vaccine, Jonathon experienced redness and swelling at the injection site and a mild fever lasting approximately one day. He documented these side effects and reported them to the clinical trial coordinators. The side effects were most likely caused by: 

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Q16. Fourteen days after the first dose of the KVD mRNA vaccine was administered, a sample of Jonathon’s blood was collected and an assay was performed to detect kipu-specific IgG and IgM antibodies. If the mRNA vaccine is effective, which of the following assay results would you expect?

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Q13. Would you recommend including an adjuvant in the KVD mRNA vaccine? Briefly justify your response. (1-2 sentences) (2 marks)

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Q12. The research team ultimately decides to develop a mRNA vaccine for protection against KVD. Which of the following statements is correct?

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