Increased gene

expression of normally silenced genes

Reduced translation of certain proteins

Loss of gene expression of essential genes

Increased translation of certain proteins

Overall gene expression would increase

Overall gene expression would not be affected

Tumour suppressor gene expression would increase

Overall gene

expression would decrease

Gene editing provides an episome, which contains the

genetic material to produce the functional protein

Gene editing machinery can be more readily delivered

to target cells than gene therapy machinery

Gene editing is

capable of permanently correcting the underlying genetic mutation

Gene editing avoids the need for delivery vectors

If the precision medicine approach is successful, the

biomarker will be absent

The amount of the biomarker present correlates with the

amount of side effects of the precision medicine treatment

If the precision medicine approach is successful, the

biomarker will have increased

Biomarkers are measurable

indicators that can inform tailored interventions

It assesses mutations, based on comparison to other

novel uncharacterised mutations within the gene of interest

It relies mainly on experimental evidence collected in

a laboratory environment

It integrates

multiple lines of evidence, including known pathogenic variants and population

frequencies

It exclusively relies on comparison to known

pathogenic mutations

To identify mutations

that may be targeted for therapeutic intervention

To identify mutations that result in the introduction

of premature stop codons

To identify mutations that result in changes to the

protein sequence

To quantify the number of mutations in the genome for

an individual

Under-expression of

the gene product may influence specific cellular processes related

to the gene product

Under-expression of the gene product will cause all other

genes to be expressed at a higher level

Cellular changes seen when the gene product is under-expressed will demonstrate the exact function of the gene product

Under-expression will cause less of the gene product

to be produced

Genomics reveals the

location of the genes, the gene's nucleotide sequence and the locations of the

mutations within specific genes

Genomics reveals which regions of a gene correspond to

the coding and non-coding regions

Genomics reveals the sequence of the genes within the

genome