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DEV3011 - Experimental developmental biology and disease modelling - S1 2026

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The figure below shows two types of viable cells derived from a parent cell after cell division (cell A and cell B). Cell B then expresses transcription factor 1 (in green) but not cell A.

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Why might cell B express the transcription factor, but not cell A? Choose the CORRECT answer.

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Consider the figure below.

What type of molecule is denoted by the black arrow? Choose the CORRECT answer

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The image below shows a gastrulating embryo of the invertebrate, Amphioxus.

What is the name given to the layer of cells denoted by the arrow? Choose the CORRECT answer.

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The image below shows an early chicken embryo during cleavage.

Which type of cleavage is depicted? Choose the CORRECT answer

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Question 6 and  7

Q6. Why do planarians have such remarkable powers of regeneration?

Q7. What value could they be in biomedical research?
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Question 5 

Cutting the planarian has a visible effect upon the colouration of the two halves of the animal. This takes about 10 minutes to become apparent.

What is this effect?
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Question 4 

Each student (or student pair) will be given a planarian worm in pond water. Observe the planarian down the dissecting microscope.

Adult planarian anatomy

Capture and image your planarian worm. Identify the following features: head, trunk, eye spot, sensory auricle, pharynx, chromatophores. (Up-load a pdf or jpeg file).
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Question 3 

“Reporter worms”.

 An example of a fluorescent reporter C. elegans

worm will be available for viewing.

a) What is the fluorescent reporter gene being used in this worm ?

b) Where in the worm is this reporter gene active?

c) What is the name of the gene it is reporting?

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Question 2 [5 marks].

a) Capture an image of the Dpy-18(ok162) ‘’Dumpy’’

mutant (1 mark). Label TWO features that

distinguishes it from the wild type worm (use arrows)  (2 marks).

b) Capture an image of the Lon-2(e678) ‘’Long’’

mutant (1 mark). Label ONE feature that

distinguishes it from the wild type worm (use arrow) (1 mark).

Note: Label your images in Photoshop or Powerpoint

(the latter is easiest) and up-load to Moodle as a single file,  as a pdf

or jpeg.

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Question 1. [ 5 marks]

Fill in the table below, matching the worm # with the correct genotype, based on the phenotype that you observe. 

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