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DEV3011 - Experimental developmental biology and disease modelling - S1 2026

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In alligator embryos, egg incubation temperature controls sex determination, where 33°C produces all male hatchlings and 30°C produces all females. Developmentally, this is an example of what sort of phenomenon?

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Consider the family pedigree below, in which a monogenic autosomal congenital abnormality is denoted by shaded squares/circles. A= dominant allele, and a = recessive allele.

Based on the pedigree shown, what is the sex and genotype of the individual denoted by the arrow?
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What modification of the HTT gene would be needed to correct Huntington’s disease in neuronal stem cells derived from an affected patient?
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What is a feature of X-inactivation?
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In understanding craniofacial development and evolution, transplants of regions of cranial neural crest between quail and duck embryos was used to demonstrate:
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In the chicken embryo hindlimb bud, a researcher has placed a bead soaked with the BMP antagonist, Noggin, in the mesoderm between cells destined to form digits 3 and 4. What is the most likely effect of this procedure? 

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A researcher has

conducted whole exome sequencing to find genes associated with neural tube defects .

What does this

method involve?

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Consider the image below.

g

What type of protein is denoted by the black arrow?

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Consider the data plot show below.

The data above derives from what sort of experiment?
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Consider the family pedigree below, in which a monogenic autosomal congenital abnormality is denoted by shaded squares/circles.

Based on the pedigree shown, what term describes the abnormality?
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