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DEV3011 - Experimental developmental biology and disease modelling - S1 2026
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GSK3-inhibiting drugs have been extensively studied as therapeutics for the treatment of Alzheimer’s’ Disease, diabetes, and some forms of cancer. In the context of intracellular signalling, what effect would a GSK3 inhibitor have in the embryo?
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Fibroblast Growth Factors are proteins.
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Craniosynostosis describes premature fusion of cranial bones in embryonic life. Most syndromic cases (those where other effects are also seen elsewhere in the body) cannot be explained. However, many can largely be attributed to mutations in genes encoding which group of proteins?
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A high concentration of Sonic hedgehog in the limb bud of a human embryo is responsible for development of the little finger (“pinkie”), but at a lower concentration it does not do so. This is an example of the effects of what type of developmental factor?
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Inhibition of Patched results in inhibition of Hedgehog signalling.
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Which of the following uses a serine-threonine kinase receptor?
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A cancer cell has a Ras mutation that keeps GTP bound to it. What is the most likely result?
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How is the interaction among two population of cells below best described?
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Beta-catenin is a kinase.
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What is a kinase?
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