PHY3202 - Nutrition, metabolism and body weight - S2 2026 Course Materials & Test Answers | learning.monash.edu

Which of the following is NOT a known mutation in

the leptin-melanocortin pathway that causes obesity in humans?

Mutations in the gene encoding for the leptin

receptor that results in truncation of the receptor and disrupted leptin

signalling.

❌

Mutations in the AgRP/NPY gene and the enzymes that

go on to produce α-MSH that leads to obesity and altered pigmentation.

✅

Mutations in the melanocortin 4 receptor (MC4R),

which is the most common monogenetic cause of obesity.

❌

Loss of function mutations in the leptin gene that

leads to severe obesity in the first months of life.

❌

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