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PHY3202 - Nutrition, metabolism and body weight - S2 2026

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Under normal physiological conditions, which of the following options correctly describes the target-tissue-specific peripheral effects of insulin?
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Activity-based anorexia model requires which two factors to be present?

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Which is the most CORRECT description of cachexia?

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How are the arcuate nucleus feeding circuits and associated brainstem pathways characteristically altered under the influence of cancer-released inflammatory cytokines in a cachectic state?

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In mouse models of cancer cachexia, how did the selective genetic knockout of the glucocorticoid receptor in skeletal muscle (mGRKO) affect the response to Lewis Lung Carcinoma (LLC)?

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When contrasting Anorexia Nervosa (AN) and Avoidant Restrictive Food Intake Disorder (ARFID), what is a key clinical characteristic essential for distinguishing ARFID from AN?
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Consider the developmental

pathways of mesenchymal stem cells and the therapeutic targets for adult body

weight regulation. Which of the following integrates a developmental growth

factor function with its corresponding adult tissue metabolic application?

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An experimental therapy aims to maximize muscle mass by blocking the pathways that restrict muscle growth. Which of the following statements correctly describes how myostatin causes muscle breakdown, and the physiological effect of blocking these pathways?

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A researcher is testing antagonists of myostatin-related growth factors to increase muscle mass. Based on the experimental results of blocking these pathways, which of the following therapeutic strategies would yield the greatest increase in Tibialis Anterior (TA) muscle mass?

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If an adult mouse is treated with a neutralizing antibody (such as JA16) that specifically blocks myostatin signalling, what is the expected physiological outcome on skeletal muscle mass?

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