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Course 10815
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Explain,
in terms of its chemical structure, why rifampin causes orange discoloration of
urine, feces, and other body secretions
Explain why pyrazinamide is considered a prodrug, and describe its mechanism of action
Explain, with reference to its chemical structure, why isoniazid may cause hepatotoxicity.
Discuss the clinically significant drug interaction of rifampicin and explain how they may affect treatment outcome.
List the major adverse effects associated with each drug in the regimen (
Explain the mechanism of action of the anti-TB drugs used in the above regimen (
What are the reason are treatment interruptions in a tuberculosis patient. Enlist at least 4 reasons from Literature.
What is the role of directly observed therapy (DOT)?
Explain the rationale for intensive and maintenance phases.
Identify key risk factors in this patient and explain how they increase susceptibility and transmission.