Explain, with reference to its chemical

structure, why isoniazid may cause hepatotoxicity.

Discuss

the clinically significant drug interaction of rifampicin and explain how they

may affect treatment outcome.

List the major adverse effects associated with

each drug in the regimen (

Explain the mechanism of action of the anti-TB drugs

used in the above regimen (

What are the reason

are treatment interruptions in a tuberculosis patient. Enlist at least 4

reasons from Literature.

What is the role of directly observed therapy

(DOT)?

Explain the rationale for intensive and

maintenance phases.

Identify key risk factors in this patient and

explain how they increase susceptibility and transmission.

Explain the pathogenesis of pulmonary TB (from

inhalation to granuloma formation).....

Explain the role of risk factors in

development of invasive candidiasis in this patient