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Hematopoiesis hepatolienal takes place

in the embryo only up to the 8th week of development.

prenatally, it is replaced by medullary hematopoiesis towards the end of the 3rd trimester.

only in lower mammals, but not in humans.

under physiological conditions to a considerable extent even in adulthood.

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the result is a non-nucleated erythrocyte with a lifespan of 100-120 days.

the reticulocyte, after extrusion of the nucleus, gives rise to the first non-nucleated stage, called the normocyte.

first, an orthochromatic erythroblast is formed, which changes into a basophilic erythroblast by the formation of hemoglobin.

is stimulated by the hormone erythropoietin, which is mainly produced by the cells of the kidney.

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has a diameter of about 15 - 20 µm.

differentiates into a promyelocyte.

arises from a hemocytoblast.

arises from the myelocyte.

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is 40-50% in a healthy man.

is a numerical value indicating the amount of hemoglobin in the erythrocyte in picograms (pg).

can be altered by pathological conditions such as inflammation, and sometimes by physiological conditions such as pregnancy.

expresses the volume ratio of formed blood elements in the blood.

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after migrating to the tissues, they become macrophages.

contain histamine and heparin in granules.

usually circulate in the peripheral circulation for about 3 days.

normally make up about 40% of all white blood cells in the peripheral circulation in a healthy person.

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Eosinophilic granulocytes

have a nucleus consisting of two segments that are connected by a chromatin bridge, which may resemble the shape of eyeglasses (spectacle shaped nucleus).

have deep blue granules.

are multiplied, e.g. in allergic patients and patients with parasitic diseases.

form 3-5% of peripheral blood leukocytes.

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Hematopoiesis takes place in an adult human

in the yolk sac.

in myeloid tissue in the bone marrow and in lymphoid tissue in the lymph nodes or spleen.

in the medulla of the thymus.

in the renal cortex and liver.

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Which statement/s is/are correct about prenatal hematopoiesis?

It occurs in the first trimester mainly in the bone marrow as medullary hematopoiesis.

One of its phases takes place in the liver and spleen primordium.

The first phase takes place in the yolk sac of the embryo.

The lymphopoiesis lineage takes place in the thymus, among others.

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Basophilic granulocytes

constitute 0.5-1% of leukocytes in the peripheral circulation.

contain basophilic, blue-staining granules that are larger than those of other granulocytes.

are precursors of tissue macrophages.

have a spherical unsegmented nucleus.

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are selected and mature in the thymus.

some of them become memory cells after activation.

can be distinguished from B-lymphocytes by the type of surface CD markers (cluster of differentiation) in the membrane.

participate in cellular immunity.

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