In type 1 diabetes (insulin-dependent diabetes mellitus), the target of the autoimmune attack is:

Following a bone

marrow transplant, which of the following therapies will be most appropriate to

inhibit T cell-mediated immunity and the development of graft-versus-host

responses? 

A 4-year-old boy is brought for evaluation

of recurrent sinus infections requiring antibiotic

treatment. He has a history of bacterial pneumonia and of chronic diarrhea. Testing reveals

significantly decreased levels of serum lgG , IgM and

mildly decreased levels of lgA. The disorder most

likely to be responsible for the findings in this

patient is 

Deletions in the T-cell CD154 (CD40L) gene produce:

A 23-year-old female has HLA genotype A3/A8,

B1/B8, C4/C1 . For each locus, the maternal allele

is listed first and the paternal allele second. Several

potential donors are available for an organ graft.

Which of the following donors would be the closest

match?

Di George syndrome results from a defect in:

Tumor antigens are presented on the cell surface by MHC class I molecules and are recognized by 

Which of the following is a non-organ-specific (systemic) autoimmune disease:

A structural similarity between microbial antigens and self-proteins may trigger an autoimmune response following a systemic infection. The T cell population selected by a pathogen may cross react with self-antigen. This is known as:

An 1 1 -year-old

with acute lymphoblastic leukemia receives a bone marrow transplant from his

older sister that contains stem cells and mature T cells. Development of which

of the following will be of primary concern in this patient?