Which statement BEST describes how the loss of E-cadherin expression can influence cancer?

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Resisting cell death via inhibiting the release of cytochrome C from the mitochondria

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Detachment of a cancer cell from the primary tumour and its transition to a migratory phenotype

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Lengthening chromosome telomeres leading to the avoidance of senescence

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Inducing angiogenesis by promoting cancer cell secretion of VEGF

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