During an immune response to a protein antigen, the affinity of the elicited antibody for antigen increases and the isotype of the antibody changes from IgM to IgG by the process of class switch recombination (CSR). Which one of the following statements is CORRECT?

Question

Accepted Answer

Because IgM is a pentamer with 10 antigen-binding sites, IgM secreted antibodies can have the same binding strength as secreted IgG despite being lower affinity

Answer

Because the same enzyme initiates CSR and somatic hypermutation (SHM), CSR and affinity maturation always occur together

Answer

IgM antibodies by definition differ in affinity to IgG antibodies

Answer

Simultaneous production of IgM and IgG is central to affinity maturation

Crowdly

During an immune response to a protein antigen, the affinity of the elicited ant...

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