The development of B cell cancers is associated with germinal centres (GC) because? Select the most accurate association.

Question

Answer

The GC is a site of intense immune activity, so the normal mechanisms of cell death can’t work there.

Answer

A failure to switch off AID in unselected B cells allows them to accumulate excess mutations, which contribute to cancer.

Answer

GC are sites of intense cellular proliferation

Answer

Targeting AID activity is imprecise which can result in mutations in genes that control the cell cycle

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