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Which one of the following is TRUE of amyotrophic lateral sclerosis (ALS)?

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Which one of the following is TRUE of amyotrophic lateral sclerosis (ALS)?

Neuronal death occurs in the brainstem and spinal cord, but not the brain.

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It is associated with mutation of superoxide dismutase 1 (SOD1).

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The primary source of reactive oxygen species (ROS) in ALS is monoamine oxidase B.

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Approximately 80-90% of cases are inherited.

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