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PHA3032 - Neuro and endocrine pharmacology - S2 2026
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In response to anti-depressant treatment, neurotransmitter levels would be expected to:
The following drugs are used in the behavioural tests to be discussed this week.
Correctly match each drug to its MAIN target/action.
The monoamine receptor hypothesis states that depression is associated with abnormalities in monoamine neurotransmitters and their receptors, such that:
For the elevated plus maze behavioural test, relative to saline control treatment, an anxiolytic drug would be expected to induce:
In the mouse forced swim test, the time that the mouse spends immobile is used as an indicator of:
Muscarinic receptor antagonists can be of benefit in treating Parkinson's disease.
Which one of the following BEST explains why?
The following is a cause/relationship question, which includes two statements - an assertion and a reason.
You must establish whether each individual statement of the pair is true or false, and then determine whether there is a relationship between the two, ie. does the reason (the second statement) provide an explanation for the assertion (first statement)?
Cholinesterase inhibitors are useful for treating Alzheimer’s disease
BECAUSE
Cholinesterase inhibitors are irreversible and stabilise a patient's cognitive state for approximately 3-5 years
In the major form of Alzheimer's disease:
In comparison with the extrinsic apoptosis pathway, the intrinsic:
The anti-epileptic drug phenytoin, undergoes metabolism by the CYP450 enzyme, 2C9.
A patient who has been stable on phenytoin for several months, is prescribed a short course of fluconazole to treat a fungal infection. Fluconazole is a 2C9 inhibitor.
If taking phenytoin and fluconazole at the same time, which one of the following is this patient MOST LIKELY to be at risk of?