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Consider the figure below, which shows comparison of an enzyme's complex with th...
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Consider the figure below, which shows comparison of an enzyme's complex with the coenzyme NAD+ (shown as orange sticks in the image below, with oxygen atoms in red and nitrogen atoms in blue) and its substrate (shown as green sticks in the image below). These data suggest that upon substrate binding, the loop comprising residues 236-246 closes over the active site, turning into a helix that keeps the substrate and reaction intermediates in place until the reaction is complete. If you perform sequence alignment of this enzyme with enzymes that catalyse the same reaction in other species, and plot the conserved residues onto the its 3D structure. The conserved residues within the 236 to 246 region will mostly likely:
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