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Conversion/ activation of a proto-oncogene into an oncogene can involve:

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Conversion/ activation of a proto-oncogene into an oncogene can involve:

A loss-of-function mutation through point mutations in both alleles

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A gain-of-function mutation through a point mutation in one allele

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Chromosomal translocation deleting a growth-regulatory gene

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A loss-of-function mutation through a point mutation in one allele

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