A patient with symptoms of mitochondrial disease presents to the emergency toom and the care team decide that an urgent diagnosis is needed. To this end, proteomics is employed using the patient peripheral blood mononuclear cells (PBMCs). The following volcano plot is obtained:

The red dots represent components of the pyruvate dehydrogenase (PDH) complex that converts pyruvate into acetyl CoA while the green dots represent proteins of the ATP synthase that produces ATP for the cell. The physician A diagnoses the patient with PDH complex deficiency while physician B thinks that the patient has ATP synthase complex deficiency. Which physician is correct?

Question

A patient with symptoms of mitochondrial disease presents to the emergency toom and the care team decide that an urgent diagnosis is needed. To this end, proteomics is employed using the patient peripheral blood mononuclear cells (PBMCs). The following volcano plot is obtained:  
  
 The red dots represent components of the pyruvate dehydrogenase (PDH) complex that converts pyruvate into acetyl CoA while the green dots represent proteins of the ATP synthase that produces ATP for the cell. The physician A diagnoses the patient with PDH complex deficiency while physician B thinks that the patient has ATP synthase complex deficiency. Which physician is correct?

Answer

Physician B is correct because the proteins of the PDH complex are unchanged in abundance compared with the control

Answer

Physician A is correct because the proteins of the PDH complex are decreased in abundance compared with the control

Answer

Physician B is correct because the proteins of the ATP synthase complex are decreased in abundance compared with the control

Answer

Physician A is correct because the proteins of the PDH complex are increased in abundance compared with the control

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A patient with symptoms of mitochondrial disease presents to the emergency toom ...

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