In the image below, there is a comparison of DMSO-treated (control) & ivacaftor treated epithelial lung cells, which contain ∆508 CFTR proteins. How could an additional experiment be used to determine how effective ivacaftor is at restoring the beat frequency of the cilia in epithelial lung cells, which contain the ∆508 CFTR proteins?

Question

Answer

Include epithelial cells that express normal (wild-type) CFTR as a reference group, measured alongside the lumacaftor-treated ∆508 epithelial cells.

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Include epithelial cells that express normal (wild-type) CFTR as a reference group, measured alongside the ivacaftor-treated ∆508 epithelial cells.

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Measure ciliary beat frequency only in ivacaftor-treated ∆508 cultures at multiple time points.

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Measure ciliary beat frequency only in ivacaftor-treated ∆508 cultures at a single timepoint

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In the image below, there is a comparison of DMSO-treated (control) & ivacaftor ...

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