The level of Separase present on chromosomes decreases with age

Cohesin plays a critical role in maintaining chromosome cohesion in meiosis I and meiosis II, and as females age there is less cohesin present

Separase degrades all Cohesin from the chromosomes to allow progression of anaphase in the first meiotic division, but this process occurs less efficiently with age

The level of Cohesin present on chromosomes increases with age