Of the choices given below, which is most frequently identified as the driving factor behind development of an antibody-mediated autoimmune disease?

Question

Answer

A breakdown in central tolerance in the bone marrow allowing self-reactive lymphocytes to develop

Answer

A genetic predisposition that is triggered by environmental agents

Answer

Infection with a pathogen that expresses antigens that mimic a self-antigen

Answer

A mutation affecting tolerance in the thymus or in Treg development

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