SSRIs' initial anxiolytic effects are attributed to their agonist action at 5-HT_2A receptors.

Buspirone decreases 5-HTergic transmission via activation of somatodendritic 5HT_1A receptors.

Benzodiazepines and buspirone are equally efficacious for treating acute anxiety.

Diazepam would be appropriate for individuals with a history of substance abuse.