In
people with familial hypercholesterolemia (FH), the LDL receptors (LDLr) in
liver cells are either absent, defective, or present in reduced numbers,
leading to impaired clearance of LDL from the bloodstream. But why does this
happen? Perhaps it is worth looking at how the LDL receptor is produced in the
first place.

Question

Answer

Once the message has been transcribed, the protein synthesis can happen
on the ribosomes present in the Endoplasmic Reticulum.

Answer

The Golgi apparatus is the site of protein synthesis where the LDL
receptor is synthesized.

Answer

Once the LDL receptors are present on the cell membrane, they can bind
LDL particles. Both the LDL particles and the LDL receptors are broken down
once they reach the lysosomes.

Answer

The instruction for making the LDL receptor molecule (which is a type of
protein) first comes from the DNA, which is situated in the nucleus.

Answer

The Golgi apparatus
is responsible for protein packaging and trafficking. It is also a site where
post-translational modifications of LDL receptors occur, such as glycosylation
of the protein, before the receptor is transported to the cell membrane.

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In people with familial hypercholesterolemia (FH), the LDL receptors (LDLr) in l...

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