IgM is secreted as a pentamer with 10 antigen-binding sites compared to 2 for IgG. Which of the following statements is consistent with this?

Question

Answer

Somatic mutations are never found in the V genes of IgM B cells because they are already high avidity

Answer

Secreted IgM can enter any tissue

Answer

IgG is used for long-term immunity because it has a lesser energy cost to synthesise and secrete

Answer

Secreted IgM can bind to antigens with an affinity lower than IgG

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