Sub neural folds of the muscle

All of the above

Synapse lying within the groove in muscle

Presence of Synaptic Cleft

Through a process that depends on the presence of Ca⁺⁺

Through a process that depends on the presence of AChE

Through exocytosis mediated by a protein called Acetyl Coenzyme A

Through endocytosis at the active zone

Through endocytosis mediated by a protein called clathrin.

The NMJ is trough-like to keep ACh from diffusing away, each vesicle has a very high [ACh], and receptors are densely packed in the endplate folds

Vesicles are pre-docked at the active zone to allow maximum exposure to Ca^++, Clathrin coating maximizes the availability of ACh, and post-synaptic receptors are widely distributed across the muscle

The NMJ is trough-like to keep ACh from diffusing away, the EPP is very large, and the EPP lasts very long

AChE can quickly degrade any excess ACh while clathrin coating promotes recycling of vesicles

Vesicles are pre-docked at the active zone to allow maximum exposure to Ca⁺⁺ , many receptors need to bind ACh to produce the EPP, and ACh binds to its receptor for longer than other transmitters

The nerve terminal is inserted into a highly folded groove of muscle with a large surface area for receptors

All of the above

The folding of the muscle end plate provides a large surface area for receptors

The axon terminal contains around 300000 vesicles of neurotransmitter

The nerve terminal is inserted into a highly folded groove of muscle

Muscarine receptors

GPCR

Nicotine adrenergic receptors

MUscarinic cholinergic receptors

Nicotine cholinergic receptors

Using Choline Acetyl trasnsferase and AChE

Using microtubules ending in vesicles

Using Choline Acetyl trasnsferase

Using secondary active transport coupled to active transport of H⁺

Using the energy released by breaking down Choline to bind to an Acetyl group

Nicotinic ACh receptors

Beta Noradrenergic receptors

Muscarinic ACh receptors

Alpha and Beta Noradrenergic receptors

Alpha Noradrenergic receptors

Muscarine receptors

GPCR

Nicotine adrenergic receptors

MUscarinic cholinergic receptors

Nicotine cholinergic receptors

Vesicles can fuse rapidly to the terminal membrane.

Otherwise AChE would degrade the Ca⁺⁺.

ACh can diffuse rapidly across the synaptic cleft.

Ca⁺⁺ facilitates ACh entry into vesicles

Synaptic vesicles are pre-docked to take advantage of the brief period of Ca⁺⁺ entry

The ability to increase intracellular calcium by 500-1000 fold for neurotransmitter release to occur

It can/will block the terminal voltage-gated calcium channels

The binding of acetylcholine vesicles to the SNARE complex

The ability for acetylcholine vesicles to be docked at the active zone

The ability of acetylcholine to attach to a receptor on the post-synaptic cleft