It enhances sodium and water retention in the kidneys.

It shifts the pressure natriuresis relationship to the left

It shifts the pressure natriuresis relationship to the right

It increases the production of renin in the kidneys. 

It increases the risk of developing major cardiovascular events by 10%.

It has no significant impact on cardiovascular health.

It increases the risk of stroke and heart failure by 13%.

 It reduces the risk of developing major cardiovascular events by approximately 10%. 

By reducing the activity of the renal nerves, which decreases sympathetic nervous system activity.

By stimulating the release of renin from the kidneys.

By increasing the production of aldosterone in the adrenal glands.

 By enhancing the reabsorption of sodium in the kidneys.

Blood pressure increases with increased salt intake

Blood pressure increases with reduced salt intake

Blood pressure decreases with increased salt intake

Blood pressure is unchanged with increased salt intake

Must be taken with other antihypertensives

Are not recommended

Are effective in the long-term

Are not effective in the long-term

kidney

all organs

lung

liver

fear of causing low blood pressure in elderly patients and increasing the risk of falls and fractures

drug induced side effects

lack of regular blood pressure monitoring

combination therapy appropriately taken is ineffective

A, B, C

B, C, D

B, D

B, C

A, B, D

A, B, C

A, B, C, D

B, C, D

135/85 mmHg

150/80 mmHg

128/89 mmHg

155/90 mmHg