Is not associated with defects in the thymic function that blocks T cell development

Are not inherited defects in the cytolytic pathway of lymphocytes

Is acquired from a virus 

Can be defects in antigen receptor gene rearrangement and results in so-called severe combined immunodeficiency (SCID)

Is not caused by inherited gene mutations

MHC class II

A specific receptor; therefore, IELs are subdivided into unlicensed and licensed IELs 

Other CD8 molecules, but do not have CD8 molecules on their cell surface

The self-specific receptor of IEL, such as KIR, must interact with self-MHC I molecules from the target cell to be functional 

MHC class I polypeptide-related sequence A (MIC-A)

Effector T cells migrate to the tumor site, where tumor cells induce an increase in MHC II expression on these T cells 

Tumor cells secrete the same serine proteases as neutrophils to evade immune detection

By activating T effector cells to target tumor cells

Decrease in MHC class I levels

Long-lived plasma cells are recruited to the tumor site to coat tumor cells with antibodies, preventing immune detection 

The lymphoma was triggered by cytomegalovirus, a member of the herpesvirus family

The chronic immune stimulation caused by the transplant has caused the lymphoma

The immune suppression required for kidney transplantation is responsible for the lymphoma

Lymphoma is the only tumor seen in transplant recipients

Graft-versus-host disease

CD40

CD28

CD89

CD5

MHC II

NK-cell licensing in the bone marrow

Complement fixation by IgM

Neutrophil extravasation

Negative selection of self-reactive T cells

Isotype switching of B cells

Destruction of the insulin-producing beta cells

Citrullination or deamination of the autoantigen myelin basic protein (MBP), specifically arginine residues within the protein, is a hallmark of demyelination and CNS disorder

Citrullination of the immunodominant collagen II peptide

Mast cells releasing high amounts of IFN-α

Proliferation and de-differentiation of keratinocytes

Because they can take up extracellular fluid by macropinocytosis

Because they are professional antigen-presenting cells

Because they are involved in negative selection in the thymus and peripheral tolerance

Because they are present in the lymph node

Because they are expressing CD4 molecules

Langerhans cells are the APCs responsible for capturing antigens in the lamina propria

Mucous produced by Goblet cells serves as a physical barrier against bacteria

M cells are only responsible for producing mucous

Physical barriers are the lineup of neutrophils

Only T follicular helper cells are abundant in the mucosa and lamina propria

Expression of HLA-DR4

Secretion of IFN-gamma

Consumption of IL-4b by CD25

Secreting anti-inflammatory cytokine/suppressive cytokines, such as TGF-𝛽, IL-10, and IL-35

Activation of cathepsin, proteasome, CD8, and exoproteases