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IMM2011 - Basic immunology: The body's defence system - S1 2025

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Name these cells in order from left to right (1 to 4):

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Which statement regarding the inflammasome is the most accurate?

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A developing thymocyte in the cortex interacts with thymic

epithelial cells. It expresses a TCR on its surface and both CD4 and CD8 coreceptors.

The TCR engages with an MHC class I molecule with a self-peptide that is

sitting in the binding cleft of the MHC. In this situation the cell will become

a CD8 positive T cell because:

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During T cell development, there is screening of the antigen receptors. The peptides that are involved in this process are:
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If in the TCR alpha chain gene locus there are 35 V region gene elements, and 45 J region gene elements and in the TCR beta chain gene locus there are 46 V region gene elements, 5 D region gene elements and 11 J region gene elements, how many different TCR combinations can be generated?
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How many unique epitopes can an individual IgM antibody recognise
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How many antigen binding sites does an IgM antibody have?
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A thymocyte is undergoing development and is at the stage of generating its antigen receptor. In the event that it does not initially generate a successful TCR beta chain, what will occur?
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Which form of recombination provides the most diversity in an antigen receptor?
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2. Using any information gained today, translate the following nucleotide sequences and indicate if they could generate a functional TCR.

TCR beta chain: TTGCACTTTGGAGCGGGCAAGATATCTTTAAGGAAACAAACGCGC

TCR alpha chain: GATCCTTATGACCGAGCTCAGGTCCAACTCCAATTCCACGGACTTAGT
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