D

A

C

E

B

Produced by the influx of Na⁺ and the efflux of Ca⁺⁺ at the motor end plate

Produced by the influx of Na⁺ and K⁺ at the motor end plate

Produced by the efflux of Na⁺ and Ca⁺⁺ at the motor end plate

Produced by the influx of Na⁺ and the efflux of K⁺ at the motor end plate

Produced by the efflux of Na⁺ and K⁺ at the motor end plate

Upregulates Ach esterase to terminate the action of Ach at the neuromuscular junction.

Blocks Ach from binding to Ach receptors, stopping efflux of Na+

Blocks Ach from binding to Ach receptors, stopping the Ca++ influx and blocks the AP from propagating in the motor end plate

 Blocks Ach vesicle release from the neuron at the neuromuscular junction, stopping Na+ influx and blocking the AP from propagating in the motor end plate

Blocks Ach from binding to Ach receptors, stopping the Na+ influx and blocks the AP from propagating in the motor end plate

The synaptic junction between alpha motoneuron and skeletal muscle

The site from the brain that innervates skeletal muscle

The specialized synaptic sites on the muscle at the NMJ

The class of motor neuron that innervates skeletal muscle

The specialized terminals of the alpha motoneuron on to skeletal muscle

Nicotinic ACh receptors

Beta Noradrenergic receptors

Muscarinic ACh receptors

Alpha and Beta Noradrenergic receptors

Alpha Noradrenergic receptors

When the AP arrives at the motneuron terminal many vesicles are already fused to the membrane and releasing their ACh molecules even prior to Ca⁺⁺ influx into the terminal with depolarization

The muscle end-plate response, the end plate potential, is very much larger than an EPSP and that gives a large safety factor even with current loss

Vesicles have high [ACh] and can dock quickly, the highly fodled endplate has a high density of Na+ and K+ channels ready to bind ACh, binding of ACh produces a large EPP

Only 10% of the AChR need to open for enough current influx to be able to spread away from the motor end plate and generate a muscle AP

Binding of ACh molecules to the nicotinic receptor lasts much longer than at other receptor-transmitter binding examples.

D

A

C

E

B

Is the ACh receptor at the motor end plate.

Produces Acetylcholine (ACh)

Binds to the ACh receptor in muscle.

Binds ACh to cause the opening of ion channels in muscle.

Is the enzyme that degrades ACh.

The Sympathetic NS post-ganglionc synapse

The Sympathetic NS pre-ganglionc synapse

The Parasympathetic NS post-ganglionc synapse

The synapse with skeletal muscle

The Parasympathetic NS pre-ganglionc synapse