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BMS2052 - Microbes in health and disease - S2 2025

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A latent HSV-1 infection in a trigeminal ganglion neuron is reactivated following host stress. You analyse protein expression in the infected cell and detect VP16, LAT, and HCF-1.

Which of these are viral proteins? (select all that apply)

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Coxsackievirus has a naked icosahedral capsid containing a positive-sense single-stranded RNA genome. 

Select the correct statement:

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Gene expression during productive replication of the DNA virus HSV1 follows which pathway?

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You are investigating an outbreak caused by a novel virus with a double-stranded genome. The viral genome is replicated in the host cell nucleus using DNA-dependent DNA polymerase.

Which Baltimore class does the virus belong to?

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Following isolation of a previously undefined virus from rodents, biochemical analysis of proteins isolated from the virion indicates that they function to convert an RNA template into DNA. 

Which of the following virus classes might this virus belong to?

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Which of the following classes of viruses include members that can complete replication using only cellular polymerases?

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The image above shows an electron micrograph of H5N1 avian influenza virions. How should these virions be classified based on their structure?

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During which stage of the viral replication cycle is the virus undetectable?

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All viruses share which of the following structural components? (select all that apply)

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A virologist isolates a novel adenovirus from a tumour sample and discovers that it selectively infects and destroys cancer cells while sparing healthy tissue. 

The virus is a strong candidate for which type of application?

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