The assembly of B-RAF

with SOS at the membrane to activate downstream MAPK signalling

The binding of B-RAF

to inactive RAS-GDP followed by phosphorylation by SOS

The

recruitment of B-RAF to active RAS-GTP at the membrane and the formation of RAF

dimers required for kinase activation

The activation of

B-RAF through direct phosphorylation by RAS after receptor stimulation

A

common epithelial skin cancer that arises from basal keratinocytes and

typically expands locally rather than metastasising

A tumour arising from

neuroendocrine cells that rapidly spreads systemically

A malignancy of

pigment-producing cells that frequently metastasises early and spreads

aggressively

A vascular tumour

associated with immunosuppression and viral infection