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PHA3032 - Neuro and endocrine pharmacology - S2 2026

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The action of prostaglandin E2 is MOST LIKELY to result in:

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C-type pain fibres are large in diameter (10-20µm) and are heavily myelinated.

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Which one of the following statements relating to inhaled general anaesthetic agents is CORRECT?

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In response to anti-depressant treatment, neurotransmitter levels would be expected to:

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The following drugs are used in the behavioural tests to be discussed this week. 

Correctly match each drug to its MAIN target/action.

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The monoamine receptor hypothesis states that depression is associated with abnormalities in monoamine neurotransmitters and their receptors, such that:

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For the elevated plus maze behavioural test, relative to saline control treatment, an anxiolytic drug would be expected to induce:

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In the mouse forced swim test, the time that the mouse spends immobile is used as an indicator of:

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Muscarinic receptor antagonists can be of benefit in treating Parkinson's disease.

Which one of the following BEST explains why?

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The following is a cause/relationship question, which includes two statements - an assertion and a reason. 

You must establish whether each individual statement of the pair is true or false, and then determine whether there is a relationship between the two, ie. does the reason (the second statement) provide an explanation for the assertion (first statement)?

Cholinesterase inhibitors are useful for treating Alzheimer’s disease

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Cholinesterase inhibitors are irreversible and stabilise a patient's cognitive state for approximately 3-5 years

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